Synthesis, characterization and antimicrobial studies on Schiff base derived from 4-amino-2-hydroxybenzoic acid and 2-hyroxybenzaldehyde and its cobalt (II) and nickel (II) complexes

Musa A.^1*, Suraj I.T.² and Sanusi S.¹

¹Department of Applied Chemistry, Federal University Dutsin-Ma, Katsina State, Nigeria

²Department of Pure and Industrial Chemistry, Bayero University Kano, Kano State, Nigeria

Abstract

A Schiff base derived from the reaction of 4-amino-2-hydroxybenzoic acid with 2-hydroxybenzaldehyde and its metal (II) complexes of Co (II) and Ni (II) were synthesized.  The IR spectral data revealed that the coordination was through the azomethine nitrogen and phenolic oxygen indicating that the Schiff base is bidentate. The molar conductance of the Co and Ni complexes were found to be 25.9 and 15.8 Ω-1cm2 Mol-1 respectively which indicated that, the complexes were non – electrolytes. The decomposition temperature of Ni (II) and Co (II) complexes were found to be 285 and 290 oC respectively, showed that the complexes are stable. The Ni (II) and Co (II) complexes exhibit Magnetic moment values of 1.79 and 5.63 BM, which suggested the complexes, are paramagnetic. Determination of metal: ligand ratio was done using Job’s method of continuous variations. The result showed a metal:ligand ratio 1:2. The biological screening of the Schiff base and its metal (II) complexes were studied against three bacterial and two fungal isolates; Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, Mucor indicus and Aspergillus flavus.  Septrin and Nystatin were used as control for the bacteria and fungi respectively. The result revealed that the complexes exhibit higher activities than the Schiff base but lower than the control.

Keywords

4-amino-2-hydroxybenzoic acid; 2-hydroxybenzaldehyde; schiff’s base; characterization; antimicrobial activity.

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