Evaluation of biochemical parameters among diabetes patients and healthy participants in a Nigerian tertiary hospital

Author(s)

Felix Olaniyi Sanni^1*, Olusoji Adeyemi², Paul Olaiya Abiodun³, Olumide Faith Ajani⁴, Freddy Rukema Kaniki⁵, Azeezat Abimbola Oyewande⁶, Andrew Nuhu Yashim⁷, Jubril Adeyinka Kareem⁸, Ajani Love Adeiye⁴, Sola Thomas Sunday⁹, Olakunle Daniel Olaniran¹⁰; ¹Department of Public Health, Triune Biblical University Global Extension, NY, USA; ²Science Laboratory Department, Kogi State University, Ayingba, Nigeria; ³Compliance and Quality control Department, Akesis, Abuja, Nigeria; ⁴Logistics and Supply Chain Management Department, Malaysia University of Science and Technology, Malaysia; ⁵Department of Public Health, Université Ebenezer de Minembwe, D.R. Congo; ⁶Family Medicine, Lagos State Health service commission, Alimosho, Lagos, Nigeria; ⁷Haematology, and blood transfusion Department, National Hospital, Abuja, Nigeria; ⁸Laboratory Services, Management Sciences for Health, Nigeria; ⁹Surveillance department, Nigeria Center for Disease Control, Jabi Abuja, Nigeria; ¹⁰Public Health Department, Texila American University, Guyana

Abstract

Background: Diabetes mellitus (DM) burden is one of the key concerns in developing countries like Nigeria. This study aimed to evaluate the biochemical parameters among diabetes patients and healthy persons in Abuja, Nigeria.

Methodology: The study was a prospective cross-sectional study that included 60 DM patients (case) and 48 healthy individuals (control) aged 19 to 80 years from April 1 and June 30, 2018. Five ml of venous fasting blood samples were obtained under aseptic precautions, and biochemical parameters were evaluated. Fasting blood glucose (FBS) and liver enzymes were determined using a fully automated biochemistry analyzer, while Haemoglobin A1c (HbA1c) was estimated by the High-performance liquid chromatography (HPLC) method. Data analysis was performed using IBM SPSS version 25, and a value of p <0.05 was taken as statistically significant.

Results: Mean FBS, HBA1c, AST, ALT, and LDH were significantly higher in DM than in control (P<0.05). Mean values of FBS and HBA1c in DM were 9.00mg/dl and 5.99%, respectively, while liver enzymes, ALT and AST, and ALP were 25.77U/L, 28.87U/L, and 214.35U/L, respectively. The mean values of cardiac enzymes, LDH, and CK-MB normal were 438.87U/L and 75.47U/L, respectively. The mean values of HBA1c, AST, ALT, ALP, LDH and CK-MB were higher than normal range in 48.3%, 16.0%, 15.0%, 23.3%, 26.6%, and 36.6% DM respectively.

Conclusion: Thus, these liver enzymes can be used as a biomarker for the assessment of diabetes. With a thorough study about the level of liver enzymes, it

is possible to monitor complications of diabetes.

Keywords

diabetes mellitus; aspartate aminotransferase; alanine aminotransferase; lactate dehydrogenase; alkaline phosphatase

Cite this paper

Sanni, F. O., Adeyemi, O., Abiodun, P. O., Ajani, O. F., Kaniki, F. R., Oyewande, A. A., Yashim, A. N., Kareem, J. A., Adeiye, A. L., Sunday, S. T., Olaniran, O. D.  (2022), Evaluation of biochemical parameters among diabetes patients and healthy participants in a Nigerian tertiary hospital, IRESPUB Journal of Life Sciences. Volume 2, Issue 1, Jan-Feb 2022, Page 1-7

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