Nano-probiotics and nano-prebiotics potential applications

Author(s)

Dieter Mason; Greenlife Laboratories, Florida, U.S.A

Abstract

Nanoparticles are everywhere, which makes them harmful. This calls for the development of nano-nutraceuticals from antioxidants, vitamins, fatty acids, fibers, probiotics, and prebiotics. In this mini-review, nanoparticles, nanolayers, nanobeads, nanoemulsions, and nanofibers are used with probiotics and prebiotics for numerous applications as found in cancer, microbial, antioxidant, and photo-reactive studies. Not so much could be discussed probably because of safety issues but a lot of practical potentials abounds.

Keywords

nanoparticles; nutraceuticals; nanoprebiotics; nanoprobiotics; applications

Cite this paper

Mason, D. (2021), Nano-probiotics and nano-prebiotics potential applications, IRESPUB Journal of Life Sciences. Volume 1, Issue 1, Sep-Oct 2021, Page 9-13

References

[1] Durazzo, A., Nazhand, A., Lucarini, M. et al. (2020). An updated overview on nanonutraceuticals: focus on nanoprebiotics and nanoprobiotics. International Journal of Molecular Sciences, 21, 2285.

[2] Sanders, M.E., Merenstein, D.J., Reid, G., Gibson, G.R. & Rastall, R.A. (2019). Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nature Reviews Gastroenterology & Hepatology, 16, 605–616.

[3] Ashaolu, T.J. (2020). Immune boosting functional foods and their mechanisms: a critical evaluation of probiotics and prebiotics. Biomedicine & Pharmacotherapy, 130, 110625.

[4] Ashaolu, T. J. (2021). Emerging applications of nanotechnologies to probiotics and prebiotics. International Journal of Food Science & Technology, 56(8), 3719–3725. doi:10.1111/ijfs.15020

[5] Rocha-Ramírez, L. M., Hernández-Ochoa, B., Gómez-Manzo, S., Marcial-Quino, J., Cárdenas-Rodríguez, N., Centeno-Leija, S., & García-Garibay, M. (2020). Evaluation of immunomodulatory activities of the heat-killed probiotic strain Lactobacillus casei IMAU60214 on macrophages in vitro. Microorganisms, 8(1), 79.

[6] Chen, Y., Zhang, L., Hong, G. et al. (2020). Probiotic mixtures with aerobic constituents promoted the recovery of multi-barriers in DSS-induced chronic colitis. Life Sciences, 240, 117089.

[7] Chen, J.C., Tsai, C.C., Hsieh, C.C., Lan, A., Huang, C.C. & Leu, S.F. (2018). Multispecies probiotics combination prevents ovalbumin-induced airway hyperreactivity in mice. Allergologia et Immunopathologia, 46, 354–360.

[8] Justino, P.F., Franco, A.X., Pontier-Bres, R. et al. (2020). Modulation of 5-fluorouracil activation of toll-like/MyD88/NF-jB/MAPK pathway by Saccharomyces boulardii CNCM I-745 probiotic. Cytokine, 125, 154791.

[9] Hsu, T.C., Yi, P.J., Lee, T.Y. & Liu, J.R. (2018). Probiotic characteristics and zearalenone-removal ability of a Bacillus licheniformis strain. PLoS One, 13, e0194866.

[10] Miraghajani, M., Zaghian, N., Mirlohi, M. & Ghiasvand, R. (2019). Probiotic soy milk consumption and renal function among type 2 diabetic patients with nephropathy: a randomized controlled clinical trial. Probiotics and Antimicrobial Proteins, 11, 124–132.

[11] Legrand, R., Lucas, N., Dominique, M. et al. (2020). Commensal Hafnia alvei strain reduces food intake and fat mass in obese mice —a new potential probiotic for appetite and body weight management. International Journal of Obesity, 44, 1041–1051.

[12] Wen, Y., Wen, P., Hu, T.G. et al. (2020). Encapsulation of phycocyanin by prebiotics and polysaccharides-based electrospun fibers and improved colon cancer prevention effects. International Journal of Biological Macromolecules, 149, 672–681.

[13] Zhu, W., Zhou, S., Liu, J., McLean, R.J. & Chu, W. (2020). Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide. Biomedicine & Pharmacotherapy, 121, 109591.

[14] Korcz, E., Kerenyi, Z. & Varga, L. (2018). Dietary fibers, prebiotics, and exopolysaccharides produced by lactic acid bacteria: potential health benefits with special regard to cholesterol-lowering effects. Food & Function, 9, 3057–3068.

[15] Cerdo, T., Garcıa-Santos, J.A., Bermudez, G. & Campoy, C. (2019). The role of probiotics and prebiotics in the prevention and treatment of obesity. Nutrients, 11, 635.

[16] Zhou, L., Xie, M., Yang, F. & Liu, J. (2020). Antioxidant activity of high purity blueberry anthocyanins and the effects on human intestinal microbiota. LWT, 117, 108621.

[17] da Silva Sabo, S., Converti, A., Todorov, S.D., Domınguez, J.M. & de Souza Oliveira, R.P. (2015). Effect of inulin on growth and bacteriocin production by Lactobacillus plantarum in stationary and shaken cultures. International Journal of Food Science & Technology, 50, 864–870.

[18] Ramos, C.I., Armani, R.G., Canziani, M.E.F. et al. (2019). Effect of prebiotic (fructooligosaccharide) on uremic toxins of chronic kidney disease patients: a randomized controlled trial. Nephrology Dialysis Transplantation, 34, 1876–1884.

[19] Khangwal, I. & Shukla, P. (2019). Prospecting prebiotics, innovative evaluation methods, and their health applications: a review. 3 Biotech, 9, 187.

[20] Hu, Q., Wu, M., Fang, C. et al. (2015). Engineering nanoparticle-coated bacteria as oral DNA vaccines for cancer immunotherapy. Nano Letters, 15, 2732–2739.

[21] Kazmierczak, R., Choe, E., Sinclair, J. & Eisenstark, A. (2015). Direct attachment of nanoparticle cargo to Salmonella typhimurium membranes designed for combination bacteriotherapy against tumors. In: Salmonella. Pp. 151–163. New York, NY: Humana Press.

[22] Song, Q., Zheng, C., Jia, J. et al. (2019). A probiotic spore-based oral autonomous nanoparticles generator for cancer therapy. Advanced Materials, 31, 1903793.

[23] Mousavi, S.M.A.A., Mirhosseini, S.A., Panahi, M.R.S. & Hosseini, H.M. (2020). Characterization of biosynthesized silver nanoparticles using Lactobacillus rhamnosus GG and its in vitro assessment against colorectal cancer cells. Probiotics and Antimicrobial Proteins, 12, 740–746.

[24] Khan, S.T., Saleem, S., Ahamed, M. & Ahmad, J. (2019). Survival of probiotic bacteria in the presence of food-grade nanoparticles from chocolates: an in vitro and in vivo study. Applied Microbiology and Biotechnology, 103, 6689–6700.

[25] Kim, W.S., Lee, J.Y., Singh, B. et al. (2018). A new way of producing pediocin in Pediococcus acidilactici through intracellular stimulation by internalized inulin nanoparticles. Scientific Reports, 8, 1– 14.

[26] Hong, L., Kim, W.S., Lee, S.M., Kang, S.K., Choi, Y.J. & Cho, C.S. (2019). Pullulan nanoparticles as prebiotics enhance the antibacterial properties of Lactobacillus plantarum through the induction of mild stress in probiotics. Frontiers in Microbiology, 10, 142.

[27] Rezaee, P., Kermanshahi, R. & Katouli, M. (2014). Prebiotics decrease the antibacterial effect of nano silver and nano TiO2 particles against probiotic bacteria of food. Current Nutrition & Food Science, 10, 88–93.

[28] Kim, W.S., Han, G.G., Hong, L. et al. (2019). Novel production of natural bacteriocin via internalization of dextran nanoparticles into probiotics. Biomaterials, 218, 119360.

[29] Zupancic, S., Skrlec, K., Kocbek, P., Kristl, J. & Berlec, A. (2019). Effects of electrospinning on the viability of ten species of lactic acid bacteria in poly (ethylene oxide) nanofibers. Pharmaceutics, 11, 483.

[30] Shahriar, S.M., Mondal, J., Hasan, M.N., Revuri, V., Lee, D.Y. & Lee, Y.K. (2019). Electrospinning nanofibers for therapeutics delivery. Nanomaterials, 9, 532.

[31] Krithika, B. & Preetha, R. (2019). Formulation of protein-based inulin incorporated synbiotic nanoemulsion for enhanced stability of probiotic. Materials Research Express, 6, 114003.