Recent healthful applications of nanoemulsions: a mini-review

Author(s)

Tolulope Joshua Ashaolu; College of Food Science, Southwest University, Beibei, Chongqing, P.R. China

Abstract

Nanotechnology is ever increasingly used in many sectors of the global community in this century. Its use in manufacturing nanoemulsions is similarly important and widely discussed recently, especially with regards to the cosmetics, pharmaceutics, and food industries due to their special characteristics of high surface area amongst others. This present mini-review focuses on nanoemulsions and their healthful applications as exemplified in drugs and vaccines delivery, cancer therapy, and inflammation treatment. The prospects, safety, and properties (e.g., stability, emulsification, solubility, molecular number and arrangements, ionic strength, pH, and temperature) of nanoemulsions were also discussed.

Keywords

nanotechnology; nanoemulsions; characteristics

Cite this paper

Ashaolu, T. J. (2021), Recent healthful applications of nanoemulsions: a mini-review , IRESPUB Journal of Life Sciences. Volume 1, Issue 1, Sep-Oct 2021, Page 1-5

References

[1] Yukuyama MN, Ghisleni DDM, Pinto TDJA et al (2016) Nanoemulsion: process selection and application in cosmetics—a review. Int J Cosmet Sci 38(1):13–24. https://doi.org/10.1111/ics.12260

[2] Azmi NAN, Elgharbawy AA, Motlagh SR et al (2019) Nanoemulsions: factory for food, pharmaceutical and cosmetics. Processes 7(9):617. https://doi.org/10.3390/pr7090617

[3] Ruthy IS (2020) A short communication on nanoemulsions. Int J Sci Advs 1(1):5-6. https://doi.org/10.51542/ijscia.v1i1.2

[4] Ashaolu TJ (2021) Nanoemulsions for health, food, and cosmetics: a review. Environ Chem Lett 19:3381–3395. https://doi.org/10.1007/s10311-021-01216-9

[5] McClements DJ, Bai L, Chung C (2017) Recent advances in the utilization of natural emulsifiers to form and stabilize emulsions. Ann Rev Food Sci Technol 8:205–236. https://doi.org/10.1146/annurev-food-030216-030154

[6] Wani TA, Masoodi FA, Jafari SM et al (2018) Safety of nanoemulsions and their regulatory status. In: Nanoemulsions. Academic Press, pp 613–628. https://www.sciencedirect.com/science/book/9780128118382

[7] Dasgupta N, Ranjan S, Gandhi M (2019b) Nanoemulsions in food: market demand. Environ Chem Lett 17(2):1003–1009. https://doi.org/10.1007/s10311-019-00856-2

[8] Mohammadi A, Jafari SM, Esfanjani AF et al (2016) Application of nano-encapsulated olive leaf extract in controlling the oxidative stability of soybean oil. Food Chem 190:513–519. https://doi.org/10.1016/j.foodchem.2015.05.115

[9] Singh KK, Vingkar SK (2008) Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine. Int J Pharm 347(1–2):136–143. https://doi.org/10.1016/j.ijpharm.2007.06.035

[10] Mansour HM, Rhee YS, Wu X (2009) Nanomedicine in pulmonary delivery. Int J Nanomed 4:299

[11] Quintão FJ, Tavares RS, Vieira-Filho SA et al (2013) Hydroalcoholic extracts of Vellozia squamata: study of its nanoemulsions for pharmaceutical or cosmetic applications. Rev Bras Farmacogn 23(1):101–107. https://doi.org/10.1590/S0102-695X2013005000001

[12] Zhao L, Seth A, Wibowo N et al (2014) Nanoparticle vaccines. Vaccine 32(3):327–337. https://doi.org/10.1016/j.vaccine.2013.11.069

[13] Akhter S, Jain GK, Ahmad FJ et al (2008) Investigation of nanoemulsion system for transdermal delivery of domperidone: ex-vivo and in vivo studies. Curr Nanosci 4(4):381–390. https://doi.org/10.2174/15734130878630607

[14] Reed SG, Bertholet S, Coler RN et al (2009) New horizons in adjuvants for vaccine development. Trends Immunol 30(1):23–32. https://doi.org/10.1016/j.it.2008.09.006

[15] Yen CC, Chen YC, Wu MT et al (2018) Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide. Int J Nanomed 13:669. https://doi.org/10.2147/IJN.S154824

[16] Aithal GC, Nayak UY, Mehta C et al (2018) Localized in situ nanoemulgel drug delivery system of quercetin for periodontitis: development and computational simulations. Molecules 23(6):1363. https://doi.org/10.3390/molecules23061363

[17] Head KA, Jurenka JS (2003) Inflammatory bowel disease part 1: ulcerative colitis–pathophysiology and conventional and alternative treatment options. Altern Med Rev 8(3):247–283

[18] Geoghegan F, Wong RWK, Rabie ABM (2010) Inhibitory effect of quercetin on periodontal pathogens in vitro. Phytother Res 24(6):817–820. https://doi.org/10.1002/ptr.3014

[19] Azuma K, Ippoushi K, Ito H et al (2002) Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. J Agric Food Chem 50(6):1706–1712. https://doi.org/10.1021/jf0112421

[20] Ganta S, Talekar M, Singh A et al (2014) Nanoemulsions in translational research—opportunities and challenges in targeted cancer therapy. AAPS PharmSciTech 15(3):694–708. https://doi.org/10.1208/s12249-014-0088-9

[21] Mahato R (2017) Nanoemulsion as targeted drug delivery system for cancer therapeutics. J Pharm Sci pharmacol 3(2):83–97. https://doi.org/10.1166/jpsp.2017.1082

[22] Ashaolu TJ, Ashaolu JO (2020) Bioactive of Whey Peptides. Int J Sci Advs 1(1):10-14. https://doi.org/10.51542/ijscia.v1i1.4

[23] Arredondo-Ochoa T, García-Almendárez BE, Escamilla-García M et al (2017) Physicochemical and antimicrobial characterization of beeswax–starch food-grade nanoemulsions incorporating natural antimicrobials. Int J Mol Sci 18(12):2712. https://doi.org/10.3390/ijms18122712

[24] Gharibzahedi SMT, Mohammadnabi S (2017) Effect of novel bioactive edible coatings based on jujube gum and nettle oil-loaded nanoemulsions on the shelf-life of Beluga sturgeon fillets. Int J Biol Macromol 95:769–777. https://doi.org/10.1016/j.ijbiomac.2016.11.119

[25] Park SJ, Hong SJ, Garcia CV et al (2019) Stability evaluation of turmeric extract nanoemulsion powder after application in milk as a food model. J Food Eng 259:12–20. https://doi.org/10.1016/j.jfoodeng.2019.04.011

[26] Mahmood Z, Jahangir M, Liaquat M et al (2017) Potential of nano-emulsions as phytochemical delivery system for food preservation. Pak J Pharm Sci 30(6):2259–2263

[27] Teo SY, Yew MY, Lee SY et al (2017) In vitro evaluation of novel phenytoin-loaded alkyd nanoemulsions designed for application in topical wound healing. J Pharm Sci 106(1):377–384.https://doi.org/10.1016/j.xphs.2016.06.028

[28] Lu WC, Huang DW, Wang CC et al (2018) Preparation, characterization, and antimicrobial activity of nanoemulsions incorporating citral essential oil. J Food Drug Anal 26(1):82–89. https://doi.org/10.1016/j.jfda.2016.12.018

[29] Shaker DS, Ishak RA, Ghoneim A et al (2019) Nanoemulsion: a review on mechanisms for the transdermal delivery of hydrophobic and hydrophilic drugs. Sci Pharm 87(3):17. https://doi.org/10.3390/scipharm87030017

[30] Kumar M, Bishnoi RS, Shukla AK et al (2019) Techniques for formulation of nanoemulsion drug delivery system: a review. Prev Nutr Food Sci 24(3):225. https://doi.org/10.3746/pnf.2019.24.3.225

[31] Gaillet S, Rouanet JM (2015) Silver nanoparticles: their potential toxic effects after oral exposure and underlying mechanisms—a review. Food Chem Toxicol 77:58–63. https://doi.org/10.1016/j.fct.2014.12.019